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The Lambda Variant in Argentina: Analyzing the Evolution and Spread of SARS-CoV-2 Lineage C.37

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dc.contributor.authorNabaes Jodar, Mercedes Soledad
dc.contributor.authorTorres, Carolina
dc.contributor.authorMojsiejczuk, Laura Noelia
dc.contributor.authorAcuña, Dolores
dc.contributor.authorValinotto, Laura Elena
dc.contributor.authorGoya, Stephanie
dc.contributor.authorNatale, Mónica Inés
dc.contributor.authorLusso, Silvina
dc.contributor.authorAlexay, Sofía
dc.contributor.authorAmadio, Ariel Fernando
dc.contributor.authorIrazoqui, José Matías
dc.contributor.authorFernández, Franco
dc.contributor.authorAcevedo, María Elina
dc.contributor.authorÁlvarez López, Cristina
dc.contributor.authorAngelletti, Andrés
dc.contributor.authorAulicino, Paula
dc.contributor.authorBolatti, Elisa María
dc.contributor.authorBrusés, Bettina Laura
dc.contributor.authorCacciahue, Marco
dc.date.accessioned2025-02-04T23:15:43Z
dc.date.available2025-02-04T23:15:43Z
dc.date.issued2023
dc.description.abstractThe second wave of COVID-19 occurred in South America in early 2021 and was mainly driven by Gamma and Lambda variants. In this study, we aimed to describe the emergence and local genomic diversity of the SARS-CoV-2 Lambda variant in Argentina, from its initial entry into the country until its detection ceased. Molecular surveillance was conducted on 9356 samples from Argentina between October 2020 and April 2022, and sequencing, phylogenetic, and phylogeographic analyses were performed. Our findings revealed that the Lambda variant was first detected in Argentina in January 2021 and steadily increased in frequency until it peaked in April 2021, with continued detection throughout the year. Phylodynamic analyses showed that at least 18 introductions of the Lambda variant into the country occurred, with nine of them having evidence of onward local transmission. The spatial–-temporal reconstruction showed that Argentine clades were associated with Lambda sequences from Latin America and suggested an initial diversification in the Metropolitan Area of Buenos Aires before spreading to other regions in Argentina. Genetic analyses of genome sequences allowed us to describe the mutational patterns of the Argentine Lambda sequences and detect the emergence of rare mutations in an immunocompromised patient. Our study highlights the importance of genomic surveillance in identifying the introduction and geographical distribution of the SARS-CoV-2 Lambda variant, as well as in monitoring the emergence of mutations that could be involved in the evolutionary leaps that characterize variants of concern.eng
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dc.identifier.citationNabaes Jodar, M. S., Torres, C., Mojsiejczuk, L., Acuña, D., Valinotto, L. E., Goya, S., Natale, M., Lusso, S., Alexay, S., Amadio, A., Irazoqui, M., Fernandez, F., Acevedo, M. E., Alvarez Lopez, C., Angelletti, A., Aulicino, P., Bolatti, E., Brusés, B., Cacciahue, M., ... Viegas, M. (2023). The Lambda Variant in Argentina: Analyzing the Evolution and Spread of SARS-CoV-2 Lineage C.37. Viruses, 15(6), pp. 1-18
dc.identifier.doihttps://doi.org/10.3390/v15061382
dc.identifier.eissn1999-4915
dc.identifier.urihttps://repositorio.unahur.edu.ar/handle/123456789/724
dc.identifier.urihttps://www.mdpi.com/1999-4915/15/6/1382
dc.journal.number6
dc.journal.pagination1-18
dc.journal.titleViruses
dc.journal.volume15
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.licenseinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ocde1Ciencias Exactas y Naturales
dc.subject.ocde2Ciencias Biológicas
dc.subject.unahurBiotecnología Aplicada
dc.titleThe Lambda Variant in Argentina: Analyzing the Evolution and Spread of SARS-CoV-2 Lineage C.37
dc.typeinfo:eu-repo/semantics/article
dc.type.oaireinfo:eu-repo/semantics/article
dc.type.snrdinfo:ar-repo/semantics/artículo
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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