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Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses

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dc.contributor.authorHollmann, Axel
dc.contributor.authorCardoso, Nancy Patricia
dc.contributor.authorEspeche, Juan Carlos
dc.contributor.authorMaffia, Paulo César
dc.date.accessioned2025-01-30T00:05:44Z
dc.date.available2025-01-30T00:05:44Z
dc.date.issued2021
dc.description.abstractViruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses
dc.description.filiationFil: Hollmann, Axel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Centro de Investigación en Biofísica Aplicada y Alimentos. - Universidad Nacional de Santiago del Estero. Centro de Investigación en Biofísica Aplicada y Alimentos; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Microbiología Molecular; Argentina
dc.description.filiationFil: Cardoso, Nancy Patricia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina
dc.description.filiationFil: Espeche, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Centro de Investigación en Biofísica Aplicada y Alimentos. - Universidad Nacional de Santiago del Estero. Centro de Investigación en Biofísica Aplicada y Alimentos; Argentina
dc.description.filiationFil: Maffia, Paulo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Instituto de Microbiologia Basica y Aplicada.; Argentina. Universidad Nacional de Hurlingham; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Microbiología Molecular; Argentina
dc.format.mimetypeapplication/pdf
dc.identifier.citationHollmann, Axel, Cardoso, Nancy Patricia, Espeche, Juan Carlos; Maffia, Paulo Cesar.(2021) Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses. Peptides; 142, 170570, 1-33
dc.identifier.doihttp://dx.doi.org/10.1016/j.peptides.2021.170570
dc.identifier.issn0196-9781
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0196978121000784
dc.identifier.urihttps://repositorio.unahur.edu.ar/handle/123456789/518
dc.journal.number170570
dc.journal.pagination1-33
dc.journal.titlePeptides
dc.journal.volume142
dc.language.isoeng
dc.publisherElsevier Science
dc.rights.licenseinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ocde1Ciencias Médicas y de la Saludes
dc.subject.ocde2Biotecnología en Salud
dc.subject.unahurBiotecnología Aplicada
dc.titleReview of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
dc.typeinfo:eu-repo/semantics/article
dc.type.oaireinfo:eu-repo/semantics/article
dc.type.snrdinfo:ar-repo/semantics/artículo
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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relation.isAuthorOfPublication.latestForDiscoveryd5be9aeb-480d-4eba-9005-f7424ceb7e77
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