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Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2 : what have we learned?

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dc.contributor.authorMozgovoj, Marina Valeria
dc.contributor.authorDidier Garnham, Mercedes Mónica
dc.contributor.authorFerrufino, Cecilia Gabriela Paola
dc.contributor.authorBlanc, Sofia
dc.contributor.authorFernández Souto, Adriana Beatríz
dc.contributor.authorPilloff, Marcela Gabriela
dc.contributor.authorDus Santos, María José
dc.date.accessioned2025-02-04T23:15:50Z
dc.date.available2025-02-04T23:15:50Z
dc.date.issued2023
dc.description.abstractAsymptomatic and presymptomatic patients played a critical role in the maintenance and spread of infection during COVID pandemic. However, conflicting views about the infectiousness of asymptomatic patients have been raised.Identification of asymptomatic cases relies on SARS-CoV-2 genome detection and, in the absence of common epidemiological variables, quantification of viral load (VL) has been proposed as an estimator for SARS-CoV-2 transmission.Comparison of VLs from symptomatic and asymptomatic patients displayed variable results according to the studied population, the experimental design and the sampling, among other variables.The aim of this work was to determine VLs in symptomatic and asymptomatic patients at the time of sampling and to retrospectively determine their relationship with severity of disease and other parameters that affected the course of COVID-19, in two towns located in Buenos Aires, Argentina.Results from our study showed that VLs from symptomatic and asymptomatic patients were significantly different when analyzed globally. In addition, significant differences were found when VLs from each COVID-19 wave were analyzed. In the first wave VLs from asymptomatic patients (log10 8,21 gc/µl) were significantly higher than in symptomatic ones (log10 6,51 gc/µl) while; in the second wave, VLs from asymptomatic patients resulted significantly lower than in symptomatic patients (log10 4,51 gc/µl and log10 5,23 gc/µl, respectively). In the third wave, no significant differences were observed between VLs from both types of patients.Results from this work demonstrated that the screening of both symptomatic and asymptomatic patients was of utmost importance in order to reduce SARS-CoV-2 transmission to communities.eng
dc.description.filiationFil: Mozgovoj, Marina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de Alimentos; Argentina. Universidad Nacional de Hurlingham.; Argentina
dc.description.filiationFil: Didier Garnham, Mercedes Monica. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.filiationFil: Ferrufino, Cecilia Gabriela Paola. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
dc.description.filiationFil: Blanc, Sofia. Universidad Nacional de Hurlingham.; Argentina
dc.description.filiationFil: Fernández Souto, Adriana Beatríz. Universidad Nacional de Hurlingham. Instituto de Educación; Argentina
dc.description.filiationFil: Pilloff, Marcela Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Hurlingham. Instituto de Biotecnología; Argentina
dc.description.filiationFil: Dus Santos, Maria Jose. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
dc.format.mimetypeapplication/pdf
dc.identifier.citationMozgovoj, Marina Valeria; Didier Garnham, Mercedes Mónica; Ferrufino, Cecilia Gabriela Paola; Blanc, Sofia; Fernández Souto, Adriana Beatriz; et al. (2023) Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned? Journal of Clinical Virology Plus; 3 (4)
dc.identifier.doihttp://dx.doi.org/10.1016/j.jcvp.2023.100166
dc.identifier.issn2667-0380
dc.identifier.urihttps://repositorio.unahur.edu.ar/handle/123456789/738
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2667038023000339
dc.journal.number4
dc.journal.titleJournal of Clinical Virology Plus
dc.journal.volume3
dc.language.isoeng
dc.publisherElsevier
dc.rights.licenseinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ocde1Ciencias Exactas y Naturales
dc.subject.ocde2Ciencias Biológicas
dc.subject.unahurBiotecnología Aplicada
dc.titleViral load in symptomatic and asymptomatic patients infected with SARS-CoV-2 : what have we learned?
dc.typeinfo:eu-repo/semantics/article
dc.type.oaireinfo:eu-repo/semantics/article
dc.type.snrdinfo:ar-repo/semantics/artículo
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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