Publication:
Cost-Effective Method to Perform SARS-CoV-2 Variant Surveillance: Detection of Alpha, Gamma, Lambda, Delta, Epsilon, and Zeta in Argentina :

Simple item page
dc.contributor.authorTorres, Carolina
dc.contributor.authorMojsiejczuk, Laura Noelia
dc.contributor.authorAcuña, Dolores
dc.contributor.authorAlexay, Sofía
dc.contributor.authorDus Santos, María José
dc.contributor.authorAmadio, Ariel Fernando
dc.date.accessioned2025-02-04T23:14:31Z
dc.date.available2025-02-04T23:14:31Z
dc.date.issued2021
dc.description.abstractSARS-CoV-2 variants with concerning characteristics have emerged since the end of 2020. Surveillance of SARS-CoV-2 variants was performed on a total of 4,851 samples from the capital city and 10 provinces of Argentina, during 51 epidemiological weeks (EWs) that covered the end of the first wave and the ongoing second wave of the COVID-19 pandemic in the country (EW 44/2020 to EW 41/2021). The surveillance strategy was mainly based on Sanger sequencing of a Spike coding region that allows the identification of signature mutations associated with variants. In addition, whole-genome sequences were obtained from 637 samples. The main variants found were Gamma and Lambda, and to a lesser extent, Alpha, Zeta, and Epsilon, and more recently, Delta. Whereas, Gamma dominated in different regions of the country, both Gamma and Lambda prevailed in the most populated area, the metropolitan region of Buenos Aires. The lineages that circulated on the first wave were replaced by emergent variants in a term of a few weeks. At the end of the ongoing second wave, Delta began to be detected, replacing Gamma and Lambda. This scenario is consistent with the Latin American variant landscape, so far characterized by a concurrent increase in Delta circulation and a stabilization in the number of cases. The cost-effective surveillance protocol presented here allowed for a rapid response in a resource-limited setting, added information on the expansion of Lambda in South America, and contributed to the implementation of public health measures to control the disease spread in Argentina.en
dc.description.filiationFil: Dus Santos, María José. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. Grupo Vinculado Incuinta al IVIT | Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas. Grupo Vinculado Incuinta al IVIT; Argentina. Universidad Nacional de Hurlingham; Argentina
dc.format.mimetypeapplication/pdf
dc.identifier.citationTorres, C., Mojsiejczuk, L.N., Acuña, D., Alexay, S., Amadio, A.F. et al.; Cost-effective method to perform SARS-CoV-2 variant surveillance: detection of Alpha, Gamma, Lambda, Delta, Epsilon, and Zeta in Argentina (2021) Frontiers Media. Frontiers 8, 1-10
dc.identifier.doihttp://dx.doi.org/10.3389/fmed.2021.755463
dc.identifier.eissn2296-858X
dc.identifier.urihttps://repositorio.unahur.edu.ar/handle/123456789/581
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fmed.2021.755463/full
dc.journal.pagination1-10
dc.journal.titleFrontiers in Medicine
dc.journal.volume8
dc.language.isoeng
dc.publisherFrontiers Media
dc.rights.licenseinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ocde1Ciencias Exactas y Naturales
dc.subject.ocde2Ciencias Biológicas
dc.subject.unahurBiotecnología Aplicada
dc.titleCost-Effective Method to Perform SARS-CoV-2 Variant Surveillance: Detection of Alpha, Gamma, Lambda, Delta, Epsilon, and Zeta in Argentina :
dc.typeinfo:eu-repo/semantics/article
dc.type.oaireinfo:eu-repo/semantics/article
dc.type.snrdinfo:ar-repo/semantics/artículo
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ART_2021_Torres_et-al_Cost_effective_method.pdf
Size:
3.06 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos de revistas