Publication:
Nodal and churchill1 position the expression of a notch ligand during Xenopus germ layer segregation

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dc.contributor.authorFavarolo, María Belén
dc.contributor.authorRevinski, Diego R.
dc.contributor.authorLópez, Silvia L.
dc.contributor.authorGaravaglia, Matías
dc.date.accessioned2024-11-15T13:46:04Z
dc.date.available2024-11-15T13:46:04Z
dc.date.issued2022
dc.description.abstractIn vertebrates, Nodal signaling plays a major role in endomesoderm induction, but germ layer delimitation is poorly understood. In avian embryos, the neural/mesoderm boundary is controlled by the transcription factor CHURCHILL1, presumably through the repressor ZEB2, but there is scarce knowledge about its role in other vertebrates. During amphibian gastrulation, Delta/Notch signaling refines germ layer boundaries in the marginal zone, but it is unknown the place this pathway occupies in the network comprising Churchill1 and Nodal. Here, we show that Xenopus churchill1 is expressed in the presumptive neuroectoderm at mid-blastula transition and during gastrulation, upregulates zeb2, prevents dll1 expression in the neuroectoderm, and favors neuroectoderm over endomesoderm development. Nodal signaling prevents dll1 expression in the endoderm but induces it in the presumptive mesoderm, from where it activates Notch1 and its target gene hes4 in the non-involuting marginal zone. We propose a model where Nodal and Churchill1 position Dll1/Notch1/Hes4 domains in the marginal zone, ensuring the delimitation between mesoderm and neuroectoderm.
dc.description.filiationFil: Favarolo, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina es
dc.description.filiationFil: Revinski, Diego Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina es
dc.description.filiationFil: Garavaglia, Matías Javier. Universidad Nacional de Hurlingham. Instituto de Biotecnologia.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina es
dc.description.filiationFil: López, Silvia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina es
dc.formatapplication/pdf
dc.identifier.citationFavarolo, María Belén, Revinski, Diego R., Garavaglia, Matías J., López, Silvia L. (2022) Nodal and churchill1 position the expression of a Notch ligand during Xenopus germ layer segregation. Life science alliance. 5 (12), 1-22
dc.identifier.issn2575-1077
dc.identifier.urihttps://repositorio.unahur.edu.ar/handle/123456789/347
dc.journal.number12
dc.journal.pagination1-20
dc.journal.titleLife science alliance
dc.journal.volume5
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.ocde1Ciencias Exactas y Naturales
dc.subject.ocde1Ciencias Biológicas
dc.subject.unahurBiotecnología Aplicada
dc.titleNodal and churchill1 position the expression of a notch ligand during Xenopus germ layer segregation
dc.type.oaireinfo:ar-repo/semantics/article
dc.type.snrdinfo:ar-repo/semantics/artículo
dc.type.unahurArtículo de revista
dspace.entity.typePublication
relation.isAuthorOfPublicationdfd74638-9eed-4460-91a7-9b41a67279fb
relation.isAuthorOfPublication.latestForDiscoverydfd74638-9eed-4460-91a7-9b41a67279fb
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