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Biomaterial-based dressings as vehicle for chitosan-encapsulated cabreuva essential oil: Cytotoxicity and regenerative activity

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datacite.subject.fosCiencias Médicas y de Saludes
datacite.subject.fosBiotecnología en Saludes
dc.contributor.authorLamarra, Javier Andrés
dc.contributor.authorBucci, Paula Lorena
dc.contributor.authorGiannuzzi, Leda
dc.contributor.authorRivero, Sandra G. M.
dc.contributor.authorPinotti, Adriana Noemí
dc.contributor.authorMartinetti Montanari, Jorge Aníbal
dc.date.accessioned2025-01-10T15:59:40Z
dc.date.available2025-01-10T15:59:40Z
dc.date.issued2020
dc.description.abstractChitosan-based emulsions functionalized with cabreuva essential oil (Myrocarpus fastigiatus) assembled with poly(vinyl alcohol) (PVA) were tailor-made to obtain a smooth, flexible and thin wound dressings capable for acting as a delivery vehicle. The cabreuva essential oil is composed mainly of trans-nerolidol, a natural compound with antimicrobial capacity that acts as a skin penetration enhancer. During the application of the dressing on skin explants, the penetration profile of cabreuva was analyzed through ex-vivo diffusion assays. Furthermore, the in-vivo essential oil delivery was followed by means of ATR-FTIR.The addition of chitosan-based emulsions produced modifications in the properties of the composite dressings associated with the water affinity and gas permeability as well as in the mechanical behavior. The dressing functionalized with cabreuva essential oil combined with chitosan proved its effectiveness against microorganisms such as S. aureus and S. epidermidis, capacity to produce cell regeneration after 24 h of contact time, and no cytotoxicity in HaCaT cells. The material developed could be used in superficial burns or minor wounds such as dressings due to its demonstrated functionality as controlled release devices of the cabreuva essential oil.
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dc.identifier.citationLamarra, Javier Andres; Bucci, Paula Lorena; Giannuzzi, Leda; Martinetti Montanari, Jorge Anibal; Rivero, Sandra G. M.; et al. (2020) Biomaterial-based dressings as vehicle for chitosan-encapsulated cabreuva essential oil: Cytotoxicity and regenerative activity. Reactive & Functional Polymers, 156, 104728
dc.identifier.isbn
dc.identifier.urihttps://repositorio.unahur.edu.ar/handle/123456789/384
dc.journal.titleReactive and Functional Polymersen
dc.journal.volume156
dc.language.isoeng
dc.publisherElsevier
dc.relation.alternativeidhttp://dx.doi.org/10.1016/j.reactfunctpolym.2020.104728
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleBiomaterial-based dressings as vehicle for chitosan-encapsulated cabreuva essential oil: Cytotoxicity and regenerative activity
dc.typeArtículo
dc.type.snrdinfo:ar-repo/semantics/artículo
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationc619b3e2-c534-47fb-aada-ccd412898176
relation.isAuthorOfPublication.latestForDiscoveryc619b3e2-c534-47fb-aada-ccd412898176
unahur.subjectBiotecnología Aplicadaes
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