Person:
Martinetti Montanari, Jorge Aníbal

Profile Picture
Email Address
Birth Date
14/05/1976
Research Projects
Organizational Units
OrgUnit Logo
Organizational Unit
Laboratorio de Nanosistemas de Aplicación Biotecnológica (LANSAB)
El Laboratorio de Nanosistemas de Aplicación Biotecnológica (LANSAB) está especializado en la encapsulación de fármacos, cosméticos, tópicos y activos naturales. Líneas de investigación: Nanotecnología aplicada a enfermedades cutáneas (cáncer de piel y leishmaniasis). Nanotecnología aplicada a formulaciones de uso veterinario. Nanotecnología aplicada a la salud del suelo. Desarrollo de nanocosméticos y nanorrepelentes.
Job Title
Investigador
Last Name
Martinetti Montanari
First Name
Jorge Aníbal
Name

Filters

20201
Reset filters

Settings

Start date: 2020 × Has files: false ×

Search Results

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Publication
    Biomaterial-based dressings as vehicle for chitosan-encapsulated cabreuva essential oil: Cytotoxicity and regenerative activity
    (Elsevier, 2020) Lamarra, Javier Andrés; Bucci, Paula Lorena; Giannuzzi, Leda; Rivero, Sandra G. M.; Pinotti, Adriana Noemí; Martinetti Montanari, Jorge Aníbal
    Chitosan-based emulsions functionalized with cabreuva essential oil (Myrocarpus fastigiatus) assembled with poly(vinyl alcohol) (PVA) were tailor-made to obtain a smooth, flexible and thin wound dressings capable for acting as a delivery vehicle. The cabreuva essential oil is composed mainly of trans-nerolidol, a natural compound with antimicrobial capacity that acts as a skin penetration enhancer. During the application of the dressing on skin explants, the penetration profile of cabreuva was analyzed through ex-vivo diffusion assays. Furthermore, the in-vivo essential oil delivery was followed by means of ATR-FTIR.The addition of chitosan-based emulsions produced modifications in the properties of the composite dressings associated with the water affinity and gas permeability as well as in the mechanical behavior. The dressing functionalized with cabreuva essential oil combined with chitosan proved its effectiveness against microorganisms such as S. aureus and S. epidermidis, capacity to produce cell regeneration after 24 h of contact time, and no cytotoxicity in HaCaT cells. The material developed could be used in superficial burns or minor wounds such as dressings due to its demonstrated functionality as controlled release devices of the cabreuva essential oil.