Person:
Calienni, María Natalia

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1991-06-10
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Laboratorio de Nanosistemas de Aplicación Biotecnológica (LANSAB)
El Laboratorio de Nanosistemas de Aplicación Biotecnológica (LANSAB) está especializado en la encapsulación de fármacos, cosméticos, tópicos y activos naturales. Líneas de investigación: Nanotecnología aplicada a enfermedades cutáneas (cáncer de piel y leishmaniasis). Nanotecnología aplicada a formulaciones de uso veterinario. Nanotecnología aplicada a la salud del suelo. Desarrollo de nanocosméticos y nanorrepelentes.
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Investigadora
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Calienni
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María Natalia
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Subject: Biotecnología Aplicada ×

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    Paclitaxel and curcumin co-loaded mixed micelles. Improving in vitro efficacy and reducing toxicity against Abraxane®
    (2021) Riedel, Jennifer Denise; Bernabeu, Ezequiel Adrián; Calabró López, María Valeria.; Calienni, María Natalia; Lázaro Martínez, Juan Manuel; Prieto, María Jimena; González, Lorena; Martínez, Carolina Soledad; Alonso Del Valle, Silvia; Martinetti Montanari, Jorge Aníbal; Evelson, Pablo Andrés; Chiappetta, Diego Andrés; Moretton, Marcela Analía
    Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its dailyoral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse nanosystems as potential strategies to reduce side effects and drug quantities. Ultradeformable liposomes, ethosomes, colloidal liquid crystals, and dendrimers were able to transport Vismodegib to deep skin layers, while polymeric micelles failed at this. As lipidic systems were the most effective, we assessed the in vitro and in vivo toxicity of Vismodegib-loaded ultradeformable liposomes, apoptosis, and cellular uptake. Vismodegib emerges as a versatile drug that can be loaded in several delivery systems for topical application. These findings may be also useful for the consideration of topical delivery of other drugs with a low water solubility.