info:eu-repo/semantics/openAccessYbarra, David EmanuelCalienni, María NataliaRamirez, Luis Felipe BarrazaAguayo Frias, Eliana TaísLillo, Rolando Cristian RodrigoAlonso Del Valle, SilviaMartinetti Montanari, Jorge AníbalAlvira, Fernando Carlos2025-01-302025-01-302022Ybarra, David Emanuel; Calienni, Maria Natalia; Ramirez, Luis Felipe Barraza; Aguayo Frias, Eliana Taís; Lillo, Rolando Cristian Rodrigo; et al. (2022) Vismodegib in PAMAM-dendrimers for potential theragnosis in skin cancer. 7; 100053-1000662352-9520https://doi.org/10.1016/j.onano.2022.100053https://www.sciencedirect.com/science/article/pii/S2352952022000160?via%3Dihubhttps://repositorio.unahur.edu.ar/handle/123456789/507Vismodegib (VDG) is an antineoplastic, a first-in-class Hedgehog signaling pathway inhibitor, indicated to treat locally advanced or metastatic basal cell carcinoma. Treatment with this drug was approved in 2012 by the US-FDA for oral administration (dose of 150 mg per day) in patients with a refusal of radiotherapy or surgery. However, it presents side effects that influence patient adherence to treatment. Polyamidoamine (PAMAM) dendrimers (D) are promising drug-delivery systems with high water solubility. Additionally, they can penetrate the skin barrier. In this work, we used amine-terminated (DG4.0) and carboxy-terminated (DG4.5) dendrimers of generation 4.0 and 4.5, respectively. We demonstrated that the complexation of VDG with dendrimers (D:VDG complexes) increased its concentration in the aqueous medium. We carried out characterization studies of the complexes to understand how dendrimers interact with VDG, and we found the optimal molar ratios of complexation.application/pdfenginfo:eu-repo/semantics/articleCiencias Médicas y de la SaludBiotecnología en SaludUna Salud. Biotecnología Aplicada